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The treatment of synoviocytes to simulate the CIA design while the remedy for SIRT1 inhibitors, we demonstrated that the inhibitory result of IL38 on inflammatory factors too as legislation of SIRT1/HIF-1α signaling pathway-related proteins had been inhibited. CONCLUSION IL-38 can restrain the inflammatory response of CIA rats, promote the phrase of osteogenic aspects, inhibit neovascularization, and relieve joint harm in rats. The device might be pertaining to the regulation of SIRT1/HIF-1α signalin