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This manuscript product reviews the fundamentals of androgen physiology, androgen synthesis and catabolism in neighborhood skin muscle, androgen receptor activity, along with the effect of hereditary polymorphisms and gender. Emphasis is positioned on the functions of androgenic activity in sebaceous gland development, sebum manufacturing , while the pathophysiology of zits vulgaris. J Drugs Dermatol. 2020;19(3 Suppl 1)s30-35.Of the four major pathogenic as
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