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Misdiagnosed sessile serrated lesions (SSLs) are important precursors for interval colorectal cancers. We investigated the usage of acetic acid (AA) solution for improving the detection of SSLs in the right colon in a randomized controlled trial. A tandem observation of the right colon was performed in 412 consecutive patients. A first inspection was performed under white light high-definition endoscopy. In the AA group, a low concentration vinegar solution (AA 0.005%) irrigated by a water pump in the right colon was compared with a pla